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Transcriptional repression mediated by the serum response factor
Author(s) -
Ernst Wolfram H.,
Janknecht Ralf,
Cahill Michael A.,
Nordheim Alfred
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01321-q
Subject(s) - psychological repression , serum response factor , serum response element , transcription factor , transcription (linguistics) , response element , activator (genetics) , microbiology and biotechnology , biology , chemistry , promoter , genetics , gene , gene expression , linguistics , philosophy
The serum response element (SRE) contributes to transcriptional repression of the c‐ fos proto‐oncogene. We show that the transcription factor SRF is able to repress SRE‐dependent transcription, apparently by sequestering a co‐activator. Only the DNA‐binding core region is required for this SRE‐dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N‐terminal repression domain affects SRE‐independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.