Premium
The reversion of highly tumorigenic cell lines to non‐tumorigenic phenotype is associated with c‐ jun down‐expression
Author(s) -
Lavrovsky Yan,
Yefremov Yaroslav,
Lavrovsky Vadim
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01266-0
Subject(s) - reversion , oncogene , phenotype , c jun , biology , transcription factor , cell culture , transcription (linguistics) , cancer research , microbiology and biotechnology , cell , gene expression , carcinogenesis , gene , cell cycle , genetics , linguistics , philosophy
Using model spontaneously reverting cell lines, c‐ jun , jun B, jun D and c‐ fos oncogene expression was investigated. c‐ jun , but not jun B, jun D or c‐ fos , was overexpressed in highly tumorigenic clones. The reversion of cells to the non‐tumorigenic phenotype resulted in a dramatic decrease in c‐ jun expression. CAT assays revealed that c‐ jun overexpression in tumorigenic cells was associated with higher transcription activity. No correlation between c‐ jun oncogene expression and AP‐1 transcription factor activity in tumorigenic and non‐tumorigenic clones was found.