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Germinating conidiospores of Aspergillus amino acid auxotrophs are hypersensitive to heat shock, oxidative stress and DNA damage
Author(s) -
Donnelly E.,
Barnett Y.A.,
McCullough W.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01207-5
Subject(s) - conidium , oxidative stress , aspergillus nidulans , mutant , biology , dna damage , auxotrophy , microbiology and biotechnology , dna , mutation , oxidative phosphorylation , biochemistry , amino acid , chemistry , gene , genetics
Germinating conidiospores (conidia) of Aspergillus nidulans amino acid‐requiring strains are hypersensitive to heat, oxidative stress, UV radiation and chemical mutagens when compared with other strains. They also showed an increased mutation rate. Sensitivity to stress conditions has been correlated with an abnormal RAS/cAMP pathway in mutants of S. cerevisiae . We suggest that the RAS/cAMP pathway is defective in germinating conidia of Aspergillus amino acid auxotrophs and that this is responsible for suppressing DNA repair and conferring sensitivity to oxidative stress and heat shock.