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Somatostatin receptor subtype SSTR2 mediates the inhibition of high‐voltage‐activated calcium channels by somatostatin and its analogue SMS 201‐995
Author(s) -
Fujii Yasukazu,
Gonoi Tohru,
Yamada Yuichiro,
Chihara Kazuo,
Inagaki Nobuya,
Seino Susumu
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01159-1
Subject(s) - somatostatin receptor 2 , somatostatin , somatostatin receptor , somatostatin receptor 1 , somatostatin receptor 3 , somatostatin analogue , chemistry , endocrinology , medicine , calcium , microbiology and biotechnology , biology , octreotide
Somatostatin and its anologue SMS 201‐995 inhibit high voltage‐activated (HVA) Ca 2+ currents in the rat insulinoma cell line RINm5F which stably express cloned human somatostatin receptor subtype 2 (hSSTR2). In contrast, neither somatostatin nor SMS 201‐995 suppresses the HVA Ca 2+ currents in RINm5F which stably express cloned hSSTR1. These results suggest that somatostatin‐induced inhibition of HVA Ca 2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca 2+ channels is one of the mechanisms of SMS 201‐995 action on inhibitory processes of hormone secretion and cell proliferation.