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A proposed structure for ‘Family 18’ chitinases a possible function for narbonin
Author(s) -
Coulson Andrew F.W.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01084-6
Subject(s) - chitinase , glycoside hydrolase , protein family , structure function , function (biology) , sequence (biology) , glycosyl , chemistry , biochemistry , domain (mathematical analysis) , biology , enzyme , genetics , physics , mathematics , gene , particle physics , mathematical analysis
The sequence of narbonin, a leguminous seed protein with the TIM barrel structure but of unknown function, is significantly similar to endo‐β‐ N ‐acetylglucosaminidase H from Streptomyces plicatus . This protein is a member of a family of chitinases, ‘Family 18’ of the glycosyl hydrolases. It is proposed that the catalytic domain of this family has the TIM barrel structure. It is proposed that narbonin has chitinase activity, or has been derived from a chitinase by loss of function.