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JAK3 Janus kinase is involved in interleukin 7 signal pathway
Author(s) -
Zeng Yi-Xin,
Takahashi Hiroshi,
Shibata Masao,
Hirokawa Katsuiku
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01065-x
Subject(s) - janus kinase , jak stat signaling pathway , tyrosine kinase 2 , microbiology and biotechnology , tyrosine phosphorylation , janus kinase 1 , signal transduction , janus kinase 3 , biology , tyrosine kinase , phosphorylation , mitogen activated protein kinase , chemistry , t cell , platelet derived growth factor receptor , immunology , biochemistry , immune system , il 2 receptor , growth factor , receptor
Interleukin (IL) 7 is an important cytokine regulating both T and B cell development and inducing the formation of lymphokine‐activated killer cells and cytolytic T lymphocytes. This study reports the role of JAK family kinases in the IL‐7 signalling pathway in a T cell clone. The results have shown that out of 4 members of JAK family tyrosine kinases (JAK1, JAK2, JAK3 and Tyk2), only JAK3 was tyrosine‐phosphorylated and activated in cells of a T cell clone by stimulation with IL‐7. Furthermore, STAT1α (STAT, the signal transducers and activators of transcription) and p44 of MAPK (mitogen‐activated protein kinases) were tyrosine phosphorylated by IL‐7 stimulation, indicating that the two signal pathways might be involved in IL‐7 signal transduction.