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Long circulating, cationic liposomes containing amino‐PEG‐phosphatidylethanolamine
Author(s) -
Zalipsky Samuel,
Brandeis Ester,
Newman Mary S.,
Woodle Martin C.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)01013-7
Subject(s) - phosphatidylethanolamine , liposome , peg ratio , cationic polymerization , chemistry , cationic liposome , chromatography , biochemistry , biophysics , phosphatidylcholine , phospholipid , organic chemistry , biology , membrane , transfection , finance , gene , economics
Ligand attachment to polyethylene glycol (PEG) grafted, long circulating liposomes at the polymer terminus is of interest for targeting but the effect of positively charged groups is unknown. Amino‐polyethylene glycol‐phosphatidylethanolamine (AminoPEG‐PE), prepared in four steps from α‐amino‐ω‐hydroxy‐PEG, was tested for influence on liposome interactions in vivo: blood circulation and biodistribution. Despite surface amines on each liposome conferring cationic behavior, in vivo properties are comparable to those obtained with methoxy‐PEG‐PE. The consequences are profound for targeting and possibly systemic delivery of cationic lipidic‐polynucleotide complexes.