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Epidermal growth factor and transforming growth factor‐α mRNA in rat small intestine: In situ hybridization study
Author(s) -
Dvořák Bohuslav,
Holubec Hana,
LeBouton Albert V.,
Wilson Jean M.,
Koldovský Otakar
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00942-2
Subject(s) - in situ hybridization , transforming growth factor , epidermal growth factor , messenger rna , small intestine , growth factor , tgf alpha , in situ , biology , microbiology and biotechnology , chemistry , endocrinology , genetics , gene , cell culture , receptor , organic chemistry
The expression of epidermal growth factor (EGF) and transforming growth factor‐α (TGF‐α) mRNA in the small intestine of suckling and adult rats was examined by in situ hybridization. EGF mRNA was found mainly in the intestinal crypts in adult rats. Adult rats also exhibited a considerably stronger signal for EGF mRNA in comparison to suckling rats, where the signal was very low or absent. In contrast to EGF, very strong expression of TGF‐α mRNA was observed in the small intestine of both adult and suckling rats. These data suggest the differences between the expression of EGF and TGF‐α in the developing small intestine.