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HMG‐X , a Xenopus gene encoding an HMG1 homolog, is abundantly expressed in the developing nervous system
Author(s) -
Kinoshita Makoto,
Hatada Seigo,
Asashima Makoto,
Noda Makoto
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00909-0
Subject(s) - xenopus , biology , neurogenesis , gene , cloning (programming) , neuroectoderm , microbiology and biotechnology , genetics , gene expression , mesoderm , embryonic stem cell , computer science , programming language
We used a PCR‐based subtraction cloning procedure with Concanavalin A‐treated and untreated animal caps from stage 9 Xenopus embryos to search for genes the expression of which is induced during neurogenesis. One of these genes was found to encode a homolog of mammalian HMG 1 and 2, hence named HMG‐X. HMG‐X mRNA was maternally transmitted, up‐regulated in neuroectoderm‐derived tissues throughout early development, and eventually down‐regulated in all adult tissues examined except ovary. Our data suggest that we have identified a gene for a member of the HMG1/2 family that could have an important role in neurogenesis.