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Sequence and structure similarities of cathepsin B from the parasite Schistosoma mansoni and human liver
Author(s) -
Klinkert Mo-Quen,
Cioli Donato,
Shaw Elliott,
Turk Vito,
Bode Wolfram,
Butler Richard
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00893-0
Subject(s) - schistosoma mansoni , cathepsin b , human liver , parasite hosting , enzyme , sequence (biology) , cathepsin l1 , cathepsin d , cathepsin , cathepsin l , biology , structural similarity , schistosoma , biochemistry , microbiology and biotechnology , chemistry , helminths , schistosomiasis , immunology , world wide web , computer science
A three‐dimensional structure of Schistosoma mansoni cathepsin B was modelled using the coordinates of the crystal structure of the human liver enzyme. Both enzymes appear to share remarkable structural similarity. However, an examination of the models complexed with two synthetic inhibitors revealed differences in inhibitor binding, as confirmed by differences in the 50% inhibitory concentration of the same inhibitor.