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No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis
Author(s) -
Hug Hubert,
Enari Masato,
Nagata Shigekazu
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00852-3
Subject(s) - apoptosis , reactive oxygen species , microbiology and biotechnology , chemistry , programmed cell death , fas receptor , oxygen , intracellular , biochemistry , biology , organic chemistry
Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)‐induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas‐mediated apoptosis and show that they are not able to block Fas‐mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)‐dependent and ‐independent mechanisms which lead to apoptosis do exist. Fas‐mediated apoptosis probably proceeds via a ROI‐independent pathway.