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src ‐related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells
Author(s) -
Bull Helen A.,
Brickell Paul M.,
Dowd Pauline M.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00814-0
Subject(s) - proto oncogene tyrosine protein kinase src , fyn , microbiology and biotechnology , angiogenesis , thrombospondin 1 , signal transduction , tyrosine kinase , thrombospondin , cd36 , biology , receptor , receptor tyrosine kinase , chemistry , cancer research , biochemistry , metalloproteinase , matrix metalloproteinase
src ‐related cytoplasmic PTKs are physically and functionally associated with cell surface receptors and are involved in signal transduction. In this paper we report the identification of src ‐related proteins p59 fyn , pp60 c‐ scr and p62 yes in human microvascular endothelial cells cultured from normal human skin and their physical association with the thrombospondin receptor CD36. Such an association represents a potential signalling pathway by which thrombospondin may regulate angiogenesis.