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Relationship between corticotropin‐releasing factor and interleukin‐2: Evolutionary evidence
Author(s) -
Ottaviani Enzo,
Franchini Antonella,
Caselgrandi Eva,
Cossarizza Andrea,
Franceschi Claudio
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00802-7
Subject(s) - corticotropin releasing hormone , chemistry , biology , endocrinology , hormone
The addition of corticotropin‐releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp. Endocrinol. 87, 354‐360]. A similar but less significant response was observed following the addition of interleukin‐2 (IL‐2). Pre‐incubation of hemocytes with IL‐2 or anti‐IL‐2 monoclonal antibody significantly reduced or completely eliminated the CRF‐induced release of biogenic amines. Further direct evidence of competition between CRF and IL‐2 was revealed by immunocytochemical and cytofluorimetric analysis. The data are compatible with the presence of a unique (ancestral?) receptor on molluscan hemocytes, capable of binding both CRF and IL‐2, two key molecules of the neuroendocrine and immune system, respectively.