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Effect of aging and acetyl‐ l ‐carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria
Author(s) -
Paradies Giuseppe,
Ruggiero Francesca Maria,
Petrosillo Giuseppe,
Gadaleta Maria Nicola,
Quagliariello Ernesto
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00763-2
Subject(s) - translocase , mitochondrion , cytochrome c oxidase , chemistry , biochemistry , carnitine , alternative oxidase , nucleotide , gene , chromosomal translocation
The effect of aging and treatment with acetyl‐ l ‐carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl‐ l ‐carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl‐ l ‐carnitine.