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cAMP‐dependent protein phosphorylation in mitochondria of bovine heart
Author(s) -
Technikova-Dobrova Zuzana,
Sardanelli Anna Maria,
Stanca Maurizio Rosario,
Papa Sergio
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00760-8
Subject(s) - cytosol , phosphorylation , protein kinase a , protein phosphorylation , mitochondrion , protein subunit , biochemistry , microbiology and biotechnology , kinase , chemistry , biology , enzyme , gene
A study is presented of the cAMP‐dependent phosphorylation in bovine heart mitochondria of three proteins of 42, 16 and 6.5 kDa associated to the inner membrane. These proteins are also phosphorylated by the cytosolic cAMP‐dependent protein kinase and by the purified catalytic subunit of this enzyme. In the cytosol, proteins of 16 and 6.5 kDa are phosphorylated by the cAMP‐dependent kinase. It is possible that cytosolic and mitochondrial cAMP‐dependent kinases phosphorylate the same proteins in the two compartments.