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α‐Dystroglycan deficiency correlates with elevated serum creatine kinase and decreased muscle contraction tension in golden retriever muscular dystrophy
Author(s) -
Ervasti James M.,
Roberds Steven L.,
Anderson Richard D.,
Sharp Nicholas J.H.,
Kornegay Joe N.,
Campbell Kevin P.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00748-9
Subject(s) - dystrophin , creatine kinase , muscular dystrophy , duchenne muscular dystrophy , medicine , endocrinology , itga7 , contraction (grammar) , chemistry
The dystrophin—glycoprotein complex was examined in dystrophin‐deficient dogs with golden retriever muscular dystrophy (GRMD) using immunoblot and immunofluorescence analysis. The dystrophin‐associated proteins were substantially reduced in muscle from dogs with GRMD. Interestingly, regression analysis revealed a strong correlation between the amount of α‐dystroglycan and serum creatine kinase levels and the contraction tension measured for a given peroneus longus muscle.