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Influence of the conformation of a macromolecule on the generation of T‐cell proliferative response A study with model polypeptides
Author(s) -
Lacassie E.,
Delmas A.,
Trudelle Y.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00708-x
Subject(s) - macromolecule , histone octamer , epitope , chemistry , proline , biophysics , cell , cell growth , biochemistry , stereochemistry , dna , biology , amino acid , histone , antibody , nucleosome , immunology
To study the influence of the conformation of polypeptidic macromolecules on the generation of T‐cell epitopes, sequential polypeptides with an octamer repeat unit were designed and synthesized. They adopt mainly unordered and α‐helical conformations. Among these polypeptides, those containing proline are fully or partly unordered, and are more effective at inducing T‐cell proliferation than a proline‐free very stable α‐helical polypeptide. This extremely stable α‐helical conformation, probably stabilized by aggregation, would enhance its stability against proteolytic processing.