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G q and G 11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells
Author(s) -
Offermanns Stefan,
Heiler Eva,
Spicher Karsten,
Schultz Günter
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00667-9
Subject(s) - bombesin , vasopressin , 3t3 cells , chemistry , biology , endocrinology , biochemistry , neuropeptide , receptor , gene , transfection
The α‐subunits of the widely expressed G‐proteins G q and G 11 indistinguishably activate β‐isoforms of phospholipase C. In this report we have tested whether differences exist in the activation of both G‐proteins via phospholipase C‐linked receptors. We found that bombesin and vasopressin, with very similar potencies and time dependencies, induce the activation of both G q and G 11 in Swiss 3T3 cells, suggesting that these G‐proteins, at least in part, serve interchangeable functions.