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Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
Author(s) -
Wenzel Thorsten,
Eckerskorn Christoph,
Lottspeich Friedrich,
Baumeister Wolfgang
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00665-2
Subject(s) - thermoplasma acidophilum , ruler , proteasome , cleavage (geology) , degradation (telecommunications) , chemistry , biochemistry , biology , computer science , enzyme , paleontology , telecommunications , physics , quantum mechanics , fracture (geology)
Analysis of the degradation products from two proteins, the insulin B‐chain and human hemoglobin, generated by archaebacterial Thermoplasma acidophilum 20 S proteasomes, revealed an unexpectedly broad specificity. In spite of the vast number of different peptides found, they fell into a rather narrow size range. This suggests that a molecular ruler exists which determines the length of the cleavage products.