Premium
Autoregulation of the human WT1 gene promoter
Author(s) -
Malik Karim T.A.,
Poirier Veronique,
Ivins Sarah M.,
Brown Keith W.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00642-3
Subject(s) - zinc finger , gene , promoter , suppressor , biology , activator (genetics) , transcriptional regulation , tumor suppressor gene , autoregulation , regulation of gene expression , microbiology and biotechnology , gene expression , genetics , cancer research , transcription factor , carcinogenesis , blood pressure , endocrinology
The human Wilms tumour suppressor gene, WT1, encodes a zinc‐finger protein which can function as a transcriptional activator or suppressor. This study reports the analysis of the human WT1 gene promoter, and demonstrates that high levels of WT1 expression lead to autosuppression of the WT1 promoter. Deletion analyses of the promoter region implicate sequences 5′ and 3′ of the transcriptional start site as being crucial in WT1 autosuppression. Loss or alteration of this function of WT1 may be important in tumourigenesis.