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A new UV‐filter compound in human lenses
Author(s) -
Truscott Roger J.W.,
Wood Andrew M.,
Carver John A.,
Sheil Margaret M.,
Stutchbury Glen M.,
Zhu Jiulin,
Kilby Greg W.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00601-6
Subject(s) - uv filter , glucoside , chemistry , fluorescence , absorption (acoustics) , tryptophan , lens (geology) , filter (signal processing) , amino acid , photochemistry , materials science , biochemistry , optics , physics , medicine , pathology , computer science , computer vision , composite material , alternative medicine
A new UV‐filter compound, 4‐(2‐amino‐3‐hydroxyphenyl)‐4‐oxobutanoic acid O ‐glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second‐most abundant UV‐filter compound in the lens with an absorption and fluorescence spectrum similar to that of 3‐hydroxykynurenine glucoside.