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Activation of human peripheral monocytes by angiotensin II
Author(s) -
Hahn Alfred W.A.,
Jonas Uwe,
Bühler Fritz R.,
Resink Thérèse J.
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00531-1
Subject(s) - angiotensin ii , monocyte , chemistry , endocrinology , tumor necrosis factor alpha , medicine , receptor , angiotensin ii receptor type 1 , renin–angiotensin system , angiotensin receptor , antagonist , blood pressure
This study has investigated the ability of the vasoconstrictor peptide angiotensin II to activate human peripheral blood monocytes. Activation was monitored by measuring both the release of tumor necrosis factor α from monocytes and their adhesion to monolayers of human endothelial cells. Angiotensin II‐elicited activation of monocytes was dose‐dependent (half‐maxiinally effective concentration ≈ 0.2 nM), saturable (maximally effective concentration ≈ 5 nM), and sensitive to inhibition by the angiotensin type 1 receptor antagonist ZD 7155. Such direct actions imply that angiotensin II is an important candidate stimulus for the subendothelial infiltration of monocytes observed in atherogenesis and hypertension.