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Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors
Author(s) -
Chiou-Fen Chuang,
S Y Ng
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00480-3
Subject(s) - map kinase kinase kinase , mitogen activated protein kinase kinase , map2k7 , ask1 , cyclin dependent kinase 9 , mapk7 , mapk/erk pathway , c raf , mitogen activated protein kinase , mapkapk2 , microbiology and biotechnology , mapk14 , cyclin dependent kinase 2 , gene isoform , biology , mitogen activated protein kinase 3 , cyclin dependent kinase 4 , signal transduction , mapk cascade , kinase , protein kinase a , gene , biochemistry
Growth factor—receptor interactions at the cell surface eventually leading to the transcriptional activation of immediate early genes is mediated by the mitogen‐activated protein kinase (MAP kinase/MAPK) cascade. Here we show that overexpression of extracellular signal‐regulated kinase 1 (ERK1) cDNA, encoding p44 mapk , results in the activation of Elk‐1, the serum response factor accessory protein. We also show that overexpression of ERK2, encoding p42 mapk , activates Myc, but not Elk‐1. Therefore, the MAP kinase cascade diverges with at least one specific target for each MAP kinase isoform and provides a novel mechanism for differential regulation of this signaling pathway.