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Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3'UUAUUUAU elements
Author(s) -
Marinx Olivier,
Bertrand Sophie,
Karsenti Eric,
Huez Georges,
Kruys Véronique
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00413-7
Subject(s) - xenopus , blastula , human fertilization , biology , microbiology and biotechnology , polyadenylation , messenger rna , untranslated region , pronucleus , gamete , polarity in embryogenesis , embryo , embryogenesis , genetics , zygote , gastrulation , gene
The early embryonic development of Xenopus is mainly governed by post‐transcriptional regulations until the mid‐blastula transition. In this report, we present evidence demonstrating that fertilization of Xenopus eggs triggers a complete translational arrest of mRNAs containing UA‐rich elements in their 3′‐untranslated region. This control is maintained at least until the mid‐blastula transition. Neither maturation nor pseudo‐fertilization of the egg is sufficient for triggering this control, suggesting that components originating from the male gamete are involved in the mechanism. Moreover, this control is exerted whether the mRNA is polyadenylated or not.