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Protein translocation: Common themes from bacteria to man
Author(s) -
Jungnickel Berit,
Rapoport Tom A.,
Hartmann Enno
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00367-x
Subject(s) - sec61 , endoplasmic reticulum , bacteria , cytoplasm , transport protein , translocon , chromosomal translocation , microbiology and biotechnology , membrane protein , chemistry , biology , biochemistry , membrane , genetics , gene
Protein transport across the endoplasmic reticulum membrane in eukaryotes and across the cytoplasmic membrane in bacteria have turned out to be highly related. The core component of the translocation apparatus is the Sec61/SecYp complex; at least two of its subunits are conserved in evolution. The Sec61/SecYp complex is involved in both co‐ and post‐translational transport pathways. The two modes require probably distinct additional components.