Premium
Regulatory squelching
Author(s) -
Cahill Michael A.,
Ernst Wolfram H.,
Janknecht Ralf,
Nordheim Alfred
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00320-3
Subject(s) - transcription (linguistics) , transcription factor , transcriptional activity , microbiology and biotechnology , chemistry , promoter , biology , gene expression , gene , biochemistry , philosophy , linguistics
An important function of transcription factors may be to sequester coactivators or corepressors of transcription. In this manner transcription factors could regulate in trans the activity of promoters to which they do not bind. This may be of widespread significance as a mechanism to control cell cycle‐dependent and differentiation‐specific transcriptional activity within eukaryotic cells. Therefore squelching in vivo may be more important than hitherto appreciated.