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Endocytosis and intracellular sorting of ricin and Shiga toxin
Author(s) -
Sandvig Kirsten,
van Deurs Bo
Publication year - 1994
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(94)00281-9
Subject(s) - ricin , endocytosis , immunotoxin , shiga toxin , endocytic cycle , toxin , cytosol , intracellular , diphtheria toxin , chemistry , microbiology and biotechnology , biochemistry , biology , receptor , escherichia coli , enzyme , cytotoxicity , in vitro , gene
Ricin and Shiga toxin belong to a group of protein toxins with targets in the cytosol. These toxins consist of one moiety that binds the toxin molecule to cell surface receptors, and another enzymatically active moiety that enters the cytosol after endocytic uptake of the toxin. The toxins are of current interest in relation to disease and the construction of immunotoxins. Moreover, they have proven useful to investigate mechanisms of endocytosis and to follow intracellular pathways of transport. Some of the recent results obtained with ricin and Shiga toxin are discussed.