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The protein import receptor MOM19 of yeast mitochondria
Author(s) -
Moczko Martin,
Gärtner Frank,
Pfanner Nikolaus
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81801-6
Subject(s) - mitochondrion , saccharomyces cerevisiae , yeast , receptor , bacterial outer membrane , biochemistry , microbiology and biotechnology , inner membrane , biology , inner mitochondrial membrane , chemistry , gene , escherichia coli
We have identified the protein import receptor MOM19 of Saccharomyces cerevisiae mitochondria. MOM19 is exposed on the outer membrane surface and present in the mitochondrial receptor complex. Antibodies raised against MOM19 strongly inhibited the import of preproteins into isolated yeast mitochondria. Fab fragments prepared from the antibodies showed the same inhibitory effect. By using mutant mitochondria, which lacked the second import receptor MOM72, we found that the import of preproteins via MOM19 did not require the presence of MOM72. We conclude that MOM19 is required for preprotein translocation across the yeast mitochondrial outer membrane and is able to function independently of the receptor MOM72.