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MFH‐1, a new member of the fork head domain family, is expressed in developing mesenchyme
Author(s) -
Miura Naoyuki,
Wanaka Akio,
Tohyama Masaya,
Tanaka Kiyoji
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81785-x
Subject(s) - mesenchyme , subfamily , mesoderm , fork (system call) , biology , head (geology) , gene , ww domain , microbiology and biotechnology , anatomy , embryo , genetics , embryonic stem cell , paleontology , computer science , operating system
We have isolated a novel mouse gene, MFH‐1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH‐1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH‐1 protein could bind to the HNF3 binding site. MFH‐1 is expressed temporally in developing embryos, first in the non‐notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH‐1 might be involved in the formation of special mesenchymal tissues.