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Expression of synaptotagmin and syntaxin associated with N‐type calcium channels in small cell lung cancer
Author(s) -
David Pascale,
El Far Oussama,
Martin-Mouto Nicole,
Poupon Marie France,
Takahashi Masami,
Seagar Michael J.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81777-w
Subject(s) - synaptotagmin 1 , syntaxin , stx1a , chemistry , syntaxin 3 , microbiology and biotechnology , calcium , voltage dependent calcium channel , synaptotagmin i , immunoprecipitation , secretion , biology , synaptic vesicle , biochemistry , exocytosis , gene , vesicle , membrane , organic chemistry
The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N‐Type calcium channels (ω)‐conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC‐1) were detected in eight. Co‐immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.