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A novel invertebrate GABA A receptor‐like polypeptide Sequence and pattern of gene expression
Author(s) -
Hutton Michael L.,
Harvey Robert J.,
Earley Fergus G.P.,
Barnard Eric A.,
Darlison Mark G.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81773-s
Subject(s) - lymnaea stagnalis , gene , biology , vertebrate , gabaa receptor , lymnaea , intron , microbiology and biotechnology , genetics , complementary dna , receptor , protein subunit , gene expression , snail , ecology
A full‐length complementary DNA has been isolated, from the fresh‐water mollusc Lymnaea stagnalis , that encodes a polypeptide (which we have named Ç) that exhibits between 30% and 40% identity to vertebrate GABA A and glycine receptor subunit sequences. The locations of seven introns have been determined in the corresponding gene and six of these occur at similar relative positions as those found in vertebrate GABA A receptor genes. RNase protection studies have revealed that the transcript for this Lymnaean polypeptide is present at highest levels in the adult nervous system but that it can also be detected in peripheral tissues.