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Downregulation of phospho‐tyrosine phosphatases in a macrophage tumor
Author(s) -
Sridhar T.S.,
Swarup G.,
Khar Ashok
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81764-q
Subject(s) - downregulation and upregulation , protein tyrosine phosphatase , biology , tyrosine , macrophage , phosphatase , receptor tyrosine kinase , receptor , microbiology and biotechnology , biochemistry , enzyme , gene , in vitro
We provide evidence for the downregulation of phospho‐tyrosine phosphatases (PTPases) in malignancy. AK‐5, a rat macrophage tumor, shows the downregulation of the transcripts of two non‐receptor‐type PTPases, PTP‐1 and PTP‐S. Though downregulated fourfold, the genomic organization of PTP‐S is unaltered. There is no gross alteration of the PTPase activity in AK‐5 as compared to macrophages. Immunoblot analysis reveals no significant change in the total phospho‐tyrosine levels in AK‐5, but there is a qualitative difference in the pattern between AK‐5 and macrophages. Our results lend credence to the conjecture that PTPases also might be involved in malignancy.