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Movable lobes and flexible loops in proteins Structural deformations that control biochemical activity
Author(s) -
Kempner E.S.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81749-p
Subject(s) - control (management) , biophysics , chemistry , microbiology and biotechnology , computer science , biology , artificial intelligence
Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexible loop over the ligand which often is trapped in a non‐aqueous environment. Biochemical reaction rates are altered dramatically by these movements.