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X‐Arrestin: a new retinal arrestin mapping to the X chromosome
Author(s) -
Murakami Akira,
Yajima Toshihiro,
Sakuma Hitoshi,
McLaren Margaret J.,
Inana George
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81712-9
Subject(s) - retina , complementary dna , biology , arrestin , in situ hybridization , retinal , homology (biology) , outer plexiform layer , microbiology and biotechnology , gene , genetics , gene expression , biochemistry , signal transduction , g protein coupled receptor , neuroscience
We have been using a differential cDNA cloning approach to isolate human retina‐specific and retina‐enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina‐specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β‐arrestin, and bovine and human retinal arrestin (S‐antigen), respectively. Chromosomal mapping localized this new arrestin genc to the proximal long arm of the X chromosome, hence it was named X‐arrestin. In situ hybridization demonstrated its expression in the inner and outer segments and the inner plexiform regions of the retina.