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Na + ,K + ‐ATPase of gastric cells A target of Helicobacter pylori cytotoxic activity
Author(s) -
Ricci V.,
Sommi P.,
Cova E.,
Fiocca R.,
Romano M.,
Ivey K.J.,
Solcia E.,
Ventura U.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81703-3
Subject(s) - cytotoxic t cell , helicobacter pylori , chemistry , microbiology and biotechnology , physics , biochemistry , biology , in vitro , genetics
The present study shows a direct impairing action of a cytotoxin‐producing Helicobacter pylori strain on the Na + ,K − ‐ATPase (evaluated as K + ‐dependent phosphatase activity) of human gastric epithelial cells in culture. The toxin itself is likely involved in this action which may also account for the cell edema found in vivo in Helicobacter pylori ‐colonized stomach.