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A hybrid protein kinase‐RNase in an interferon‐induced pathway?
Author(s) -
Bork Peer,
Sander Chris
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81701-z
Subject(s) - rnase p , protein kinase a , rnase mrp , c raf , protein kinase r , mitogen activated protein kinase kinase , two hybrid screening , signal transduction , map2k7 , cyclin dependent kinase 9 , biology , biochemistry , microbiology and biotechnology , chemistry , yeast , kinase , cyclin dependent kinase 2 , rna , gene
The sequence of RNase L has been re‐examined by computer analysis. We propose a molecular architecture of RNase L, with an unusual combination, in one protein chain, of 9 ankyrin‐like repeats, a functional active protein kinase and a C‐terminal catalytic RNase similar to the yeast protein, IRE1. The protein kinase may be involved in a new signal transduction pathway which remains to be discovered.