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Interleukin‐10 inhibits endotoxin‐induced tissue factor mRNA production by human monocytes
Author(s) -
Ramani M.,
Ollivier V.,
Khechai F.,
Vu T.,
Ternisien C.,
Bridey F.,
de Prost D.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81693-t
Subject(s) - tissue factor , septic shock , disseminated intravascular coagulation , monocyte , cytokine , activator (genetics) , coagulation , interleukin , immunology , chemistry , microbiology and biotechnology , biology , sepsis , medicine , biochemistry , gene
In Gram‐negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin‐10 (IL‐10) on endotoxin‐induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.