Premium
A comment on the absence of calcium regulation of human thioredoxin reductase
Author(s) -
Oblong John E.,
Powis Garth
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81667-o
Subject(s) - thioredoxin reductase , chemistry , thioredoxin , calcium , biochemistry , microbiology and biotechnology , biology , enzyme , organic chemistry
It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra‐ and extracellular physiological levels. Furthermore, the suggestion that an E‐F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.