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Metabolic channelling and control of the flux
Author(s) -
Kholodenko Boris N.,
Westerhoff Hans V.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81660-r
Subject(s) - channelling , flux (metallurgy) , metabolite , metabolism , enzyme , chemistry , physics , biophysics , biochemistry , biology , ion , organic chemistry
Metabolic control theory is extended to include channelled metabolism in general. A simple relationship between the flux control by the enzymes and the degree of metabolite channelling is derived. This relationship suggests experiments in which modulation of gene expression allows one to quantify channelling.