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Proteasome and cell cycle
Author(s) -
Richter-Ruoff Birgit,
Wolf Dieter H.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81603-w
Subject(s) - proteasome , cell cycle , microbiology and biotechnology , regulator , cyclin , cyclin dependent kinase 1 , mitosis , polo like kinase , biology , cyclin a , cyclin dependent kinase , cyclin b , cell cycle protein , biochemistry , chemistry , cell , gene
The cell cycle of eukaryotic cells is strictly regulated. This regulation is performed by a serine/threonine kinase. The different functions of this kinase in the cell cycle are modulated by different cyclins, which fluctuate in concentration (‘cycle’) during the different stages of the cell cycle. Using yeast as a model organism we show here that the activity of the multifunctional proteinase, the proteasome, is directly connected to the function of the mitotic cyclin Clb2. Our studies indicate that the proteasome is the proteolytic regulator of this cyclin and thus a central regulator of the cell cycle.