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Adenine dinucleotide‐mediated cytosolic free Ca 2+ oscillations in single hepatocytes
Author(s) -
Green Anne K.,
Dixon C.Jane,
McLennan Alexander G.,
Cobbold Peter H.,
Fisher Michael J.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81567-j
Subject(s) - aequorin , cytosol , chemistry , biophysics , hepatocyte , biochemistry , biology , intracellular , enzyme , in vitro
Single rat hepatocytes microinjected with aequorin respond to Ca 2+ ‐mobilizing agonists, including ADP and ATP, with oscillations in cytosolic free Ca 2+ . We show here that single rat hepatocytes also respond to the adenine dinucleotides Ap 3 A and Ap 4 A with Ca 2+ oscillations which resemble those induced by ADP and ATP.