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The structure of human carbonic anhydrase II in complex with bromide and azide
Author(s) -
Jönsson B.M.,
Håkansson K.,
Liljas A.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81565-h
Subject(s) - carbonic anhydrase , azide , chemistry , bromide , biochemistry , carbonic anhydrase ii , enzyme , inorganic chemistry , organic chemistry
The three‐dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non‐protonated inhibitors replace the zinc and the ‘deep’ water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 Å from the zinc water position, respectively, but are in close contact (2.0 and 2.6 Å, respectively) with the zinc ion.