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Endothelin‐1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase Evidence for involvement in stimulation of mitogenesis
Author(s) -
Wilkes Lesley C.,
Patel Viral,
Purkiss John R.,
Boarder Michael R.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81556-f
Subject(s) - vascular smooth muscle , stimulation , tyrosine kinase , phospholipase , chemistry , endocrinology , endothelin 1 , medicine , microbiology and biotechnology , phospholipase a2 , smooth muscle , biology , signal transduction , biochemistry , enzyme , receptor
The mechanism whereby endothelin stimulates motogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin‐1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phospholipase D in the mitogenic response.