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Augmentation of human natural killer cells by splenopentin analogs
Author(s) -
Rastogi A.,
Singh V.K.,
Biswas S.,
Haq W.,
Mathur K.B.,
Agarwal S.S.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81498-o
Subject(s) - pentapeptide repeat , in vitro , natural killer cell , chemistry , cell , biological activity , biochemistry , stereochemistry , biology , microbiology and biotechnology , peptide , cytotoxicity
Splenopentin, Arg‐Lys‐Glu‐Val‐Tyr (SP‐5) and its synthetic analogs; Arg‐ d ‐Lys‐Glu‐Val‐Tyr (pentapeptide 1), Lys‐Lys‐Glu‐Val‐Tyr (2), d ‐Lys‐Lys‐Glu‐Val‐Tyr (3), Arg‐Lys‐Gly‐Val‐Tyr (4), and Arg‐Lys‐Gln‐Val‐Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T‐cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.