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Naturally occurring deuterium is essential for the normal growth rate of cells
Author(s) -
Somlyai Gábor,
Jancsó Gábor,
Jákli György,
Vass Kornélia,
Barna Balázs,
Lakics Viktor,
Gaál Tamás
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81479-j
Subject(s) - deuterium , chemistry , transplantation , cell growth , fibroblast , cell , signal transduction , cell culture , microbiology and biotechnology , biology , biochemistry , medicine , in vitro , genetics , quantum mechanics , physics
The role of naturally occurring D in living organisms has been examined by using deuterium‐depleted water (30–40 ppm D) instead of water containing the natural abundance of D (150 ppm). The deuterium‐depleted water significantly decreased the growth rate of the L 929 fibroblast cell line, and also inhibited the tumor growth in xenotransplanted mice. Eighty days after transplantation in 10 (59%) out of 17 tumorous mice the tumor, after having grown, regressed and then disappeared. We suggest that the naturally occurring D has a central role in signal transduction involved in cell cycle regulation.