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WWamide‐1, ‐2 and ‐3: novel neuromodulatory peptides isolated from ganglia of the African giant snail, Achatina fulica
Author(s) -
Minakata Hiroyuki,
Ikeda Tetsuya,
Muneoka Yojiro,
Kobayashi Makoto,
Nomoto Kyosuke
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81458-c
Subject(s) - achatina , snail , biology , neuropeptide , neuron , anatomy , chemistry , neuroscience , biochemistry , ecology , receptor
Three novel neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica , were named WWamide‐1, ‐2 and ‐3. These substances were biologically active heptapeptide amides with a Trp residue at both the N‐ and C‐termini. WWamide‐1, which displayed an inhibitory activity on a central neuron of the snail, exhibited peripherally modulatory effects on muscular contractions of not only the gut and other tissues of the snail but also certain tissues of other molluscs.