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RNA editing in trypanosome mitochondria: guidelines for models
Author(s) -
Sloof Paul,
Benne Rob
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81431-x
Subject(s) - rna editing , guide rna , rna , biology , microrna , computational biology , non coding rna , messenger rna , uridine , rna silencing , microbiology and biotechnology , genetics , rna interference , crispr , genome editing , gene
Mitochondrial RNAs in trypanosomes are post‐transcriptionally altered by uridine insertion and deletion. The information for these RNA editing processes, which are essential for the production of functional messengers, is provided by small guide RNAs. This article discusses how features of partially edited RNAs, gRNAs and chimeric RNAs, in which a gRNA is covalently linked to an editing site of pre‐mRNA, have been used for the construction of models.