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The unique properties of glutamate receptor channels
Author(s) -
Sprengel R.,
Seeburg P.H.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81420-5
Subject(s) - glutamate receptor , ion channel , neurotransmission , excitatory postsynaptic potential , biophysics , chemistry , neuroscience , protein subunit , ligand gated ion channel , central nervous system , conductance , biology , biochemistry , microbiology and biotechnology , receptor , gene , mathematics , combinatorics
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by synaptically released l ‐glutamate which activates cation selective channels with different kinetic and ion conductance properties. Studies with cloned glutamate receptor channels helped delineate the functional properties of channels defined in subunit composition. Moreover, molecular studies have revealed novel genetic mechanisms controlling the expression of important structural channel determinants.