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Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta
Author(s) -
Simmaco Maurizio,
Mignogna Giuseppina,
Barra Donatella,
Bossa Francesco
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81384-c
Subject(s) - frog skin , antimicrobial peptides , rana , antimicrobial , peptide , staphylococcus aureus , secretion , microbiology and biotechnology , antibacterial peptide , biology , biochemistry , chemistry , antibacterial activity , bacteria , anatomy , genetics , organic chemistry , sodium
Three antimicrobial peptides were isolated from skin secretion of the European frog, Rana esculenta . Two of them show similarity to brevinin‐1 and brevinin‐2, respectively, two antimicrobial peptides recently isolated from a Japanese frog [Morikawa, N., Hagiwara, K. and Nakajima, T. (1992) Biochem. Biophys. Res. Commun. 189, 184‐190]. The third one, named esculentin, is 46 residues long and represents a different type of peptide. All these peptides have as a common motif an intramolecular disulfide bridge located at the COOH‐terminal end. The peptides from R . esculenta show distinctive antibacterial activity against representative Gram‐negative and Gram‐positive bacterial species. In particular, esculentin is the most active against Staphylococcus aureus , and has a much lower hemolytic activity.