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Prediction of a novel topology in the N‐terminal, 14 kDa fragment of ada protein
Author(s) -
Swindells Mark B.
Publication year - 1993
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(93)81352-z
Subject(s) - fragment (logic) , topology (electrical circuits) , folding (dsp implementation) , terminal (telecommunication) , protein folding , protein structure , chemistry , crystallography , computational biology , computer science , biology , biochemistry , algorithm , mathematics , combinatorics , engineering , telecommunications , electrical engineering
Previously determined protein structures have been analysed, in order to find folding motifs similar to that proposed by NMR spectroscopy, for the N‐terminal, 14 kDa fragment of the Ada protein. The analyses reveal only limited similarities with the NMR‐derived structural data and strongly suggest that this region of the Ada protein adopts a previously unobserved topology. Characteristic structural features, which arise from the inferred chain connectivity, are examined through comparisons with other structures. Using this information, the topology of the Ada protein 14 kDa fragment has been predicted in order to provide structural data not yet attainable from NMR experiments.